Integrin beta 7 Antikörper (C-Term)

Produktnummer ABIN2798921

Der Kaninchen Polyklonal Anti-Integrin beta 7-Antikörper wurde für WB validiert. Er ist geeignet, Integrin beta 7 in Proben von Human zu detektieren.

Kurzübersicht für Integrin beta 7 Antikörper (C-Term) (ABIN2798921)

Target: Integrin beta 7 (ITGB7)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin beta 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Integrin beta 7 Antikörper

Bindungsspezifität: AA 737-765, C-Term

Verwendungszweck: Rabbit Anti-Human ITGB7 (C-term) Antibody

Immunogen: This ITGB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ITGB7.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000ITGB7 Antibody (C-term) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Andere Bezeichnung: ITGB7

Hintergrund:

Target Description: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Gene Symbol: ITGB7

Molekulargewicht: 86903 Da

Gen-ID: 3695

UniProt: P26010

Pathways: Integrin Complex