SNX6 Antikörper (N-Term)

Produktnummer ABIN2798685

Dieses Anti-SNX6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SNX6 in WB. Geeignet für Human.

Kurzübersicht für SNX6 Antikörper (N-Term) (ABIN2798685)

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SNX6 Antikörper

Bindungsspezifität: AA 81-110, N-Term

Verwendungszweck: Rabbit Anti-Human SNX6 (N-term) Antibody

Immunogen: This SNX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human SNX6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of SNX6 Antibody (N-term) was detected using the purified Pab.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.0 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Andere Bezeichnung: SNX6

Hintergrund:

Target Description: SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Gene Symbol: SNX6

Molekulargewicht: 46649 Da

Gen-ID: 58533

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway