Chiffon Antikörper (C-Term)
Kurzübersicht für Chiffon Antikörper (C-Term) (ABIN2798594)
Target
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 476-504, C-Term
-
Verwendungszweck
- Rabbit Anti-Human CHFR (C-term) Antibody
-
Immunogen
- This CHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human CHFR.
-
Isotyp
- Ig Fraction
-
-
anti-Chiffon (CHIF) (AA 476-504), (C-Term) antibody
CHIF Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
-
-
Applikationshinweise
-
Western Blot
Recommended Dilutions
WB: 1:1000CHFR Antibody (C-term) . -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 0.5 mg/mL
-
Lagerung
- 4 °C,-20 °C
-
Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
-
-
- Chiffon (CHIF)
-
Andere Bezeichnung
- CHF
-
Hintergrund
-
Target Description: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Gene Symbol: CHFR
-
Molekulargewicht
- 73386 Da
-
Gen-ID
- 55743
-
UniProt
- Q96EP1
Target
-
