PRDM6 Antikörper (N-Term)

Produktnummer ABIN2798584

Produktdetails anti-PRDM6 Antikörper

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Bindungsspezifität: AA 44-72, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit Anti-Human PRDM6 (N-term) Antibody

Immunogen: This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000PRDM6 Antibody (N-term) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.350 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Andere Bezeichnung: PRDM6 (PRDM6 Produkte)

Hintergrund:

Target Description: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Gene Symbol: PRDM6

Molekulargewicht: 64452 Da

Gen-ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation