SGOL2 Antikörper (Center)

Produktnummer ABIN2795993

Der Kaninchen Polyklonal Anti-SGOL2-Antikörper wurde für WB validiert. Er ist geeignet, SGOL2 in Proben von Human zu detektieren.

Kurzübersicht für SGOL2 Antikörper (Center) (ABIN2795993)

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SGOL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SGOL2 Antikörper

Bindungsspezifität: AA 391-419, Center

Verwendungszweck: Rabbit Anti-Human SGOL2 (Center) Antibody

Immunogen: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot
Recommended Dilutions
WB: 1:1000SGOL2 Antibody (Center) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu SGOL2

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Andere Bezeichnung: SGOL2

Hintergrund:

Target Description: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Gene Symbol: SGOL2

Molekulargewicht: 144739 Da

Gen-ID: 151246

UniProt: Q562F6