HAS2 Antikörper (Center)

Produktnummer ABIN2794747

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HAS2 in WB, IHC und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HAS2 Antikörper (Center) (ABIN2794747)

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-HAS2 Antikörper

Bindungsspezifität: AA 138-166, Center

Verwendungszweck: Rabbit Anti-Human HAS2 (Center) Antibody

Immunogen: This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the Central region of human HAS2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50HAS2 Antibody (Center) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Andere Bezeichnung: HAS2

Hintergrund:

Target Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Gene Symbol: HAS2

Molekulargewicht: 63566 Da

Gen-ID: 3037

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process