Caveolin 2 Antikörper (N-Term)

Produktnummer ABIN2792220

Der Kaninchen Polyklonal Anti-Caveolin 2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Caveolin 2 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf und Pferd zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Caveolin 2 Antikörper (N-Term) (ABIN2792220)

Target: Caveolin 2 (CAV2)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caveolin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Caveolin 2 Antikörper

Bindungsspezifität: N-Term

Sequenz: LVIPYNEKPE KPAKTQKTSL DEALQWRDSL DKLLQNNYGL ASFKSFLKSE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CAV2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAV2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 162 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Caveolin 2 Antikörper (ABIN2792220)

Chi Sabins, Taylor, Fabian, Appleman, Maranchie, Stolz, Storkus: "DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 21, Issue 10, pp. 1958-68, (2013) (PubMed).

Details zu Caveolin 2

Target: Caveolin 2 (CAV2)

Andere Bezeichnung: CAV2

Hintergrund: CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.
Alias Symbols: CAV, MGC12294
Protein Interaction Partner: EGFR, PTGS1, CSNK2A1, CAV1, MALL, KCNMA1, UBC, DNAJA1, GOLGB1, NCK1, SRC, RASA1, FLOT2, DRD1, PLD2,
Protein Size: 162

Molekulargewicht: 18 kDa

Gen-ID: 858

NCBI Accession: NM_001233, NP_001224

UniProt: P51636

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development