Cyclin T1 Antikörper (N-Term)

Produktnummer ABIN2792158

Der Kaninchen Polyklonal Anti-Cyclin T1-Antikörper wurde für WB validiert. Er ist geeignet, Cyclin T1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Ziege, Pferd, Meerschweinchen und Kaninchen zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Cyclin T1 Antikörper (N-Term) (ABIN2792158)

Target: Cyclin T1 (CCNT1)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Ziege, Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin T1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cyclin T1 Antikörper

Bindungsspezifität: N-Term

Sequenz: EGERKNNNKR WYFTREQLEN SPSRRFGVDP DKELSYRQQA ANLLQDMGQR

Homologie: Cow: 100%, Dog: 92%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CCNT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CCNT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 726 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Cyclin T1 Antikörper (ABIN2792158)

Sun, Zheng, Zhao, Lee, Goldstein: "Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide" in: Journal of virology, Vol. 82, Issue 11, pp. 5562-72, (2008) (PubMed).

Details zu Cyclin T1

Target: Cyclin T1 (CCNT1)

Andere Bezeichnung: CCNT1

Hintergrund: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CCNT, CYCT1, HIVE1
Protein Interaction Partner: tat, LARP7, AFF1, CDK9, BRD4, HEXIM1, UBC, SUMO1, NEDD8, RN7SK, SUPT5H, SOX2, CTD, MBP, AFF4, ELL2, MED26, MLLT3, ESR1, DAB2, CCNT1, BRDT, BARD1, TAF1, RPS9, GNAI3, LEO1, C11orf58, TUBB4B, TP53BP1, KMT2A, UBE2A, POLR2A, GTF2F1, TAF7, Ep300, Gata4, TERF2,
Protein Size: 726

Molekulargewicht: 81 kDa

Gen-ID: 904

NCBI Accession: NM_001240, NP_001231

UniProt: O60563