ASCL1 Antikörper (Middle Region)

Produktnummer ABIN2792096

Der Kaninchen Polyklonal anti-ASCL1 Antikörper wird verwendet zum Nachweis von ASCL1 in Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen und Hund. Er wurde validiert für WB.

Kurzübersicht für ASCL1 Antikörper (Middle Region) (ABIN2792096)

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ASCL1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: AGVLSPTISP NYSNDLNSMA GSPVSSYSSD EGSYDPLSPE EQELLDFTNW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ASCL1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ASCL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 236 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Andere Bezeichnung: ASCL1

Hintergrund: ASCL1 may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. ASCL1 is essential for the generation of olfactory and autonomic neurons. ASCL1 activates transcription by binding to the E box (5'-CANNTG-3').This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ASH1, HASH1, MASH1, bHLHa46
Protein Interaction Partner: MEF2D, MEF2C, MEF2A, NEUROG2, UBQLN1, EP300, TCF4, BMP2, ASCL1,
Protein Size: 236

Molekulargewicht: 25 kDa

Gen-ID: 429

NCBI Accession: NM_004316, NP_004307

UniProt: P50553

Pathways: Dopaminergic Neurogenesis