BCR Antikörper (N-Term)

Produktnummer ABIN2792051

Der Kaninchen Polyklonal anti-BCR Antikörper wird verwendet zum Nachweis von BCR in Proben von Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen, Rind (Kuh) und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für BCR Antikörper (N-Term) (ABIN2792051)

Target: BCR (Breakpoint Cluster Region (BCR))

Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BCR Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: BCR Antibody - N-terminal region

Sequenz: EDFSSGQSSR VSPSPTTYRM FRDKSRSPSQ NSQQSFDSSS PPTPQCHKRH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against BCR-ABL1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human BCR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP72510-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Andere Bezeichnung: BCR

Hintergrund:

Background Information: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: breakpoint cluster region

Alternative Symbols: ALL, CML, PHL, BCR1, D22S11, D22S662

Protein Name: breakpoint cluster region protein

Molekulargewicht: 34kDa

Gen-ID: 613

NCBI Accession: NP_004318

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling