VHLL Antikörper (N-Term)

Produktnummer ABIN2791981

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch VHLL in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für VHLL Antikörper (N-Term) (ABIN2791981)

Target: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VHLL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-VHLL Antikörper

Bindungsspezifität: N-Term

Sequenz: PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu VHLL

Target: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Andere Bezeichnung: VHLL

Hintergrund: Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
Alias Symbols: VHLP, VLP
Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
Protein Size: 139

Molekulargewicht: 15 kDa

Gen-ID: 391104

NCBI Accession: NM_001004319, NP_001004319

UniProt: Q6RSH7