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VHLL Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch VHLL in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN2791981

Kurzübersicht für VHLL Antikörper (N-Term) (ABIN2791981)

Target

Alle VHLL Antikörper anzeigen
VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Reaktivität

Human

Wirt

  • 6
  • 3
Kaninchen

Klonalität

  • 7
  • 2
Polyklonal

Konjugat

  • 5
  • 2
  • 1
  • 1
Dieser VHLL Antikörper ist unkonjugiert

Applikation

  • 6
  • 3
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 6
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    PWRAGNGVGL EAQAGTQEAG PEEYCQEELG AEEEMAARAA WPVLRSVNSR

    Homologie

    Human: 100%

    Produktmerkmale

    This is a rabbit polyclonal antibody against VHLL. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N-terminal region of Human VHLL
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeat freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

    Andere Bezeichnung

    VHLL

    Hintergrund

    Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
    Alias Symbols: VHLP, VLP
    Protein Interaction Partner: RBPMS, DAZAP2, HIF1A,
    Protein Size: 139

    Molekulargewicht

    15 kDa

    Gen-ID

    391104

    NCBI Accession

    NM_001004319, NP_001004319

    UniProt

    Q6RSH7
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