MVB12B Antikörper (C-Term)

Produktnummer ABIN2791520

Der Kaninchen Polyklonal anti-MVB12B Antikörper wird verwendet zum Nachweis von MVB12B in Proben von Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für MVB12B Antikörper (C-Term) (ABIN2791520)

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MVB12B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MVB12B Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: MVB12B Antibody - C-terminal region

Sequenz: HISLTLPATF RGRNSTRTDY EYQHSNLYAI SAMDGVPFMI SEKFSCVPES

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MVB12B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MVB12B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP70312-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MVB12B

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Andere Bezeichnung: MVB12B

Hintergrund:

Targeted Subunit: 12B

Background Information: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative Symbols: C9orf28, FAM125B

Protein Name: Multivesicular body subunit 12B

Molekulargewicht: 35kDa

Gen-ID: 89853

NCBI Accession: NP_258257

UniProt: Q9H7P6