PLD6 Antikörper (C-Term)

Produktnummer ABIN2791346

Der Kaninchen Polyklonal anti-PLD6 Antikörper (ABIN2791346) detektiert spezifisch PLD6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PLD6 Antikörper (C-Term) (ABIN2791346)

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLD6 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PLD6 Antibody - C-terminal region

Sequenz: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP69458-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Andere Bezeichnung: PLD6

Hintergrund:

Background Information: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Alternative Symbols: ZUC

Protein Name: Mitochondrial cardiolipin hydrolase

Molekulargewicht: 28kDa

Gen-ID: 201164

NCBI Accession: NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization