PLD6 Antikörper (C-Term)

Produktnummer ABIN2791346

Dieses Anti-PLD6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLD6 in WB. Geeignet für Human.

Kurzübersicht für PLD6 Antikörper (C-Term) (ABIN2791346)

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLD6 Antikörper

Bindungsspezifität: C-Term

Sequenz: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 252 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Andere Bezeichnung: PLD6

Hintergrund: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
Alias Symbols: -
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 252

Molekulargewicht: 28 kDa

Gen-ID: 201164

NCBI Accession: NM_178836, NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization