MACROD1 Antikörper (N-Term)

Produktnummer ABIN1545234

Dieser Anti-MACROD1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von MACROD1 in WB. Geeignet für Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus und Ratte.

Kurzübersicht für MACROD1 Antikörper (N-Term) (ABIN1545234)

Target: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MACROD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MACROD1 Antikörper

Bindungsspezifität: N-Term

Sequenz: MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 325 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MACROD1

Target: MACROD1 (MACRO Domain Containing 1 (MACROD1))

Andere Bezeichnung: MACROD1

Hintergrund: MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
Alias Symbols: LRP16
Protein Interaction Partner: BAG3, EPB41,
Protein Size: 325

Molekulargewicht: 36 kDa

Gen-ID: 28992

NCBI Accession: NM_014067, NP_054786

UniProt: Q9BQ69