RRP8 Antikörper (N-Term)

Produktnummer ABIN2791071

Produktdetails anti-RRP8 Antikörper

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GKKGKKKCQK QGPPCSDSEE EVERKKKCHK QALVGSDSAE DEKRKRKCQK

Homologie: Cow: 83%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 456 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RRP8

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Andere Bezeichnung: RRP8 (RRP8 Produkte)

Synonyme: KIAA0409 antikoerper, 1500003O22Rik antikoerper, 2900001K19Rik antikoerper, AW538116 antikoerper, RGD1308302 antikoerper, ribosomal RNA processing 8 antikoerper, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antikoerper, RRP8 antikoerper, Rrp8 antikoerper

Hintergrund: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Alias Symbols: KIAA0409
Protein Interaction Partner: RNF2, SIRT7, SIRT1, SUV39H1, USP39,
Protein Size: 456

Molekulargewicht: 50 kDa

Gen-ID: 23378

NCBI Accession: NM_015324, NP_056139

UniProt: O43159