IYD Antikörper (N-Term)

Produktnummer ABIN2790550

Der Kaninchen Polyklonal anti-IYD Antikörper (ABIN2790550) detektiert spezifisch IYD in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Rind (Kuh), Hund und Kaninchen.

Kurzübersicht für IYD Antikörper (N-Term) (ABIN2790550)

Target: IYD (Iodotyrosine Deiodinase (IYD))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IYD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IYD Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: IYD Antibody - N-terminal region

Sequenz: NADRSMEKKK GEPRTRAEAR PWVDEDLKDS SDLHQAEEDA DEWQESEENV

Homologie: Cow: 77%, Dog: 79%, Human: 100%, Rabbit: 79%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against IYD. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human IYD

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP66837-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu IYD

Target: IYD (Iodotyrosine Deiodinase (IYD))

Andere Bezeichnung: IYD

Hintergrund:

Background Information: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.

Alternative Symbols: TDH4, IYD-1, DEHAL1, C6orf71

Protein Name: Iodotyrosine dehalogenase 1

Molekulargewicht: 27kDa

Gen-ID: 389434

NCBI Accession: NP_001158167

UniProt: Q6PHW0

Pathways: Thyroid Hormone Synthesis