CHMP5 Antikörper (C-Term)

Produktnummer ABIN2790285

Der Kaninchen Polyklonal Anti-CHMP5-Antikörper wurde für WB validiert. Er ist geeignet, CHMP5 in Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für CHMP5 Antikörper (C-Term) (ABIN2790285)

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CHMP5 Antikörper

Bindungsspezifität: C-Term

Sequenz: LDALGDELLA DEDSSYLDEA ASAPAIPEGV PTDTKNKDGV LVDEFGLPQI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against Chmp5. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Chmp5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 219 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CHMP5

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Andere Bezeichnung: Chmp5

Hintergrund: Chmp5 is a probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Alias Symbols: 2210412K09Rik, AW545668
Protein Interaction Partner: Ndn,
Protein Size: 219

Molekulargewicht: 24 kDa

Gen-ID: 76959

NCBI Accession: NM_029814, NP_084090

UniProt: Q9D7S9