Latrophilin 1 Antikörper (C-Term)

Produktnummer ABIN2790265

Produktdetails anti-Latrophilin 1 Antikörper

Target: Latrophilin 1 (LPHN1)

Bindungsspezifität: C-Term

Reaktivität: Ratte, Human, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Latrophilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YSLRSGDFPP GDGGPEPPRG RNLADAAAFE KMIISELVHN NLRGSSSAAK

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against LPHN1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LPHN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 839 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Latrophilin 1

Target: Latrophilin 1 (LPHN1)

Andere Bezeichnung: LPHN1 (LPHN1 Produkte)

Hintergrund: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.
Alias Symbols: CIRL1, CL1, LEC2
Protein Interaction Partner: PSMA3, ELAVL1, UBC, CACNA1A, APC, ANKS1A, SHANK1, SHANK2, DLG4, DLG3, ROS1,
Protein Size: 839

Molekulargewicht: 95 kDa

Gen-ID: 22859

NCBI Accession: NM_001008701

UniProt: O94910

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis