SPAG1 Antikörper (N-Term)

Produktnummer ABIN2790231

Der Kaninchen Polyklonal anti-SPAG1 Antikörper wird verwendet zum Nachweis von SPAG1 in Proben von Human und Hund. Er wurde validiert für WB.

Kurzübersicht für SPAG1 Antikörper (N-Term) (ABIN2790231)

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Reaktivität: Human, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SPAG1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SPAG1 Antibody - N-terminal region

Sequenz: LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH

Homologie: Dog: 85%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPAG1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human SPAG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65711-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SPAG1

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Andere Bezeichnung: SPAG1

Hintergrund:

Background Information: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Gene Name: sperm associated antigen 1

Alternative Symbols: SP75, TPIS, CT140, CILD28, DNAAF13, HSD-3.8, HEL-S-268

Protein Name: sperm-associated antigen 1

Molekulargewicht: 45kDa

Gen-ID: 6674

NCBI Accession: NP_003105

UniProt: G3XAM3