SPAG1 Antikörper (N-Term)

Produktnummer ABIN2790231

Der Kaninchen Polyklonal Anti-SPAG1-Antikörper wurde für WB validiert. Er ist geeignet, SPAG1 in Proben von Human und Hund zu detektieren.

Kurzübersicht für SPAG1 Antikörper (N-Term) (ABIN2790231)

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Reaktivität: Human, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SPAG1 Antikörper

Bindungsspezifität: N-Term

Sequenz: LHVGKEKYSK RPTKKKTPRD YAEWDKFDVE KECLKIDEDY KEKTVIDKSH

Homologie: Dog: 85%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPAG1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human SPAG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPAG1

Target: SPAG1 (Sperm Associated Antigen 1 (SPAG1))

Andere Bezeichnung: SPAG1

Hintergrund: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Alias Symbols: SP75, TPIS, CT140, CILD28, HSD-3.8, HEL-S-268
Protein Size: 416

Molekulargewicht: 45 kDa

Gen-ID: 6674

NCBI Accession: NM_003114, NP_003105

UniProt: G3XAM3