DEF6 Antikörper (C-Term)

Produktnummer ABIN2790082

Der Kaninchen Polyklonal anti-DEF6 Antikörper (ABIN2790082) detektiert spezifisch DEF6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Meerschweinchen, Pferd und Kaninchen.

Kurzübersicht für DEF6 Antikörper (C-Term) (ABIN2790082)

Target: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DEF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DEF6 Antikörper

Bindungsspezifität: C-Term

Sequenz: QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DEF6

Target: DEF6 (Differentially Expressed in FDCP 6 Homolog (DEF6))

Andere Bezeichnung: DEF6

Hintergrund: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Alias Symbols: C6.1A, BRCC36, CXorf53
Protein Size: 376

Molekulargewicht: 41 kDa

Gen-ID: 79184

NCBI Accession: NM_001018055, NP_001018065

UniProt: P46736