Sortilin 1 Antikörper (C-Term)

Produktnummer ABIN2789904

Produktdetails anti-Sortilin 1 Antikörper

Target: Sortilin 1 (SORT1)

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sortilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SORT1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 831 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Sortilin 1

Target: Sortilin 1 (SORT1)

Andere Bezeichnung: SORT1 (SORT1 Produkte)

Synonyme: SORT1 antikoerper, 19.m02079 antikoerper, gp95 antikoerper, ldlcq6 antikoerper, sortilin antikoerper, Gp95 antikoerper, LDLCQ6 antikoerper, NT3 antikoerper, 2900053A11Rik antikoerper, AI852375 antikoerper, Ntr3 antikoerper, Ntsr3 antikoerper, Nt3 antikoerper, Nts3 antikoerper, sort1 antikoerper, zgc:85953 antikoerper, sortilin 1 antikoerper, sortilin antikoerper, sortilin 1 S homeolog antikoerper, sortilin 1a antikoerper, SORT1 antikoerper, TP01_0016 antikoerper, BBOV_I002730 antikoerper, sort1.S antikoerper, Sort1 antikoerper, sort1a antikoerper

Hintergrund: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes, however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p, the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Alias Symbols: Gp95, NT3
Protein Interaction Partner: NUDCD3, UBC, SORCS1, GGA1, GGA3, GGA2, STAM, ELAVL1, NTS, NGF, NGFR, BDNF, LRPAP1, CDK2, SLC2A4,
Protein Size: 831

Molekulargewicht: 84 kDa

Gen-ID: 6272

NCBI Accession: NM_002959, NP_002950

UniProt: Q99523

Pathways: Neurotrophin Signalübertragung