KIR2DS2 Antikörper (N-Term)

Produktnummer ABIN2789655

Der Kaninchen Polyklonal anti-KIR2DS2 Antikörper wird verwendet zum Nachweis von KIR2DS2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für KIR2DS2 Antikörper (N-Term) (ABIN2789655)

Target: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR2DS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIR2DS2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: KIR2DS2 Antibody - N-terminal region

Sequenz: ETVILQCWSD VRFEHFLLHR EGKYKDTLHL IGEHHDGVSK ANFSIGPMMQ

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIR2DS2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63891-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu KIR2DS2

Target: KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor 2DS2 (KIR2DS2))

Andere Bezeichnung: KIR2DS2

Hintergrund:

Background Information: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene Name: Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2

Alternative Symbols: NKAT5, cl-49, CD158J, CD158b, NKAT-5, 183ActI, KIR2DL1, KIR-2DS2

Protein Name: KIR2DS2 EMBL ACX71621.1

Molekulargewicht: 32kDa

Gen-ID: 100132285

NCBI Accession: NP_036444

UniProt: D0UWM7