HCAR2 Antikörper (C-Term)

Produktnummer ABIN2789654

Produktdetails anti-HCAR2 Antikörper

Target: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCAR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YYFSSPSFPN FFSTLINRCL QRKMTGEPDN NRSTSVELTG DPNKTRGAPE

Homologie: Cow: 91%, Guinea Pig: 92%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HCAR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 363 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HCAR2

Target: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Andere Bezeichnung: HCAR2 (HCAR2 Produkte)

Synonyme: GPR109A antikoerper, HCA2 antikoerper, HM74a antikoerper, HM74b antikoerper, NIACR1 antikoerper, PUMAG antikoerper, Puma-g antikoerper, Gpr109a antikoerper, Gpr109b antikoerper, HM74 antikoerper, Hcar2 antikoerper, PUMA-G antikoerper, Pumag antikoerper, mHM74b antikoerper, HCAR2 antikoerper, HCAR3 antikoerper, hydroxycarboxylic acid receptor 2 antikoerper, HCAR2 antikoerper, Hcar2 antikoerper, LOC527744 antikoerper

Hintergrund: HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Alias Symbols: HM74a, HM74b, NIACR1, PUMAG, Puma-g
Protein Size: 363

Molekulargewicht: 42 kDa

Gen-ID: 338442

NCBI Accession: NM_177551, NP_808219

UniProt: Q8TDS4