RASGRP1 Antikörper (C-Term)

Produktnummer ABIN2789624

Dieses Anti-RASGRP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RASGRP1 in WB. Geeignet für Human, Meerschweinchen, Maus, Kaninchen, Rind (Kuh), Hund, Pferd und Ratte.

Kurzübersicht für RASGRP1 Antikörper (C-Term) (ABIN2789624)

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reaktivität: Human, Meerschweinchen, Maus, Kaninchen, Rind (Kuh), Hund, Pferd, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASGRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RASGRP1 Antikörper

Bindungsspezifität: C-Term

Sequenz: LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RASGRP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 797 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Andere Bezeichnung: RASGRP1

Hintergrund: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alias Symbols: CALDAG-GEFI, CALDAG-GEFII, MGC129998, MGC129999, RASGRP, V, hRasGRP1
Protein Interaction Partner: Dlg4, ABCB8, DGKZ, HRAS, VHL, PPM1B,
Protein Size: 797

Molekulargewicht: 90 kDa

Gen-ID: 10125

NCBI Accession: NM_005739, NP_005730

UniProt: O95267

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung