Sclerostin Antikörper (N-Term)

Produktnummer ABIN2789538

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Sclerostin in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen, Hund, Schwein, Pferd, Rind (Kuh) und Meerschweinchen.

Kurzübersicht für Sclerostin Antikörper (N-Term) (ABIN2789538)

Target: Sclerostin (SOST)

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Schwein, Pferd, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sclerostin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Sclerostin Antikörper

Bindungsspezifität: N-Term

Sequenz: PELGEYPEPP PELENNKTMN RAENGGRPPH HPFETKDVSE YSCRELHFTR

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SOST. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 213 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Sclerostin

Target: Sclerostin (SOST)

Andere Bezeichnung: SOST

Hintergrund: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Alias Symbols: VBCH
Protein Interaction Partner: LRP6, LRP5,
Protein Size: 213

Molekulargewicht: 23 kDa

Gen-ID: 50964

NCBI Accession: NM_025237, NP_079513

UniProt: Q9BQB4