Sclerostin Antikörper (N-Term)

Produktnummer ABIN2789538

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Sclerostin in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen, Hund, Schwein, Pferd, Rind (Kuh) und Meerschweinchen.

Kurzübersicht für Sclerostin Antikörper (N-Term) (ABIN2789538)

Target: Sclerostin (SOST)

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Schwein, Pferd, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sclerostin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Sclerostin Antikörper

Bindungsspezifität: N-Term

Sequenz: PELGEYPEPP PELENNKTMN RAENGGRPPH HPFETKDVSE YSCRELHFTR

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SOST. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 213 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Sclerostin

Target: Sclerostin (SOST)

Andere Bezeichnung: SOST

Hintergrund: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Alias Symbols: VBCH
Protein Interaction Partner: LRP6, LRP5,
Protein Size: 213

Molekulargewicht: 23 kDa

Gen-ID: 50964

NCBI Accession: NM_025237, NP_079513

UniProt: Q9BQB4