MCAM Antikörper (Middle Region)

Produktnummer ABIN2789518

Produktdetails anti-MCAM Antikörper

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Bindungsspezifität: Middle Region

Reaktivität: Human, Kaninchen, Schwein, Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PSTREAEEET TNDNGVLVLE PARKEHSGRY ECQGLDLDTM ISLLSEPQEL

Homologie: Cow: 86%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against MCAM. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 646 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Andere Bezeichnung: MCAM (MCAM Produkte)

Synonyme: CD146 antikoerper, MUC18 antikoerper, Muc18 antikoerper, 1-gicerin antikoerper, AV025631 antikoerper, CD149 antikoerper, s-endo antikoerper, s-gicerin antikoerper, cd146 antikoerper, gicerin antikoerper, id:ibd3512 antikoerper, mcam antikoerper, MCAM antikoerper, melanoma cell adhesion molecule antikoerper, melanoma cell adhesion molecule b antikoerper, MCAM antikoerper, Mcam antikoerper, mcamb antikoerper

Hintergrund: MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Alias Symbols: CD146, MUC18
Protein Interaction Partner: ADRB2, UBC, HSP90AA5P, HSPA1L, ATF7IP, PTK2B, FYN,
Protein Size: 646

Molekulargewicht: 71 kDa

Gen-ID: 4162

NCBI Accession: NM_006500, NP_006491

UniProt: P43121