MCAM Antikörper (Middle Region)

Produktnummer ABIN2789518

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MCAM in WB. Es zeigt Reaktivität gegenüber Proben von Human, Kaninchen, Schwein, Pferd und Rind (Kuh).

Kurzübersicht für MCAM Antikörper (Middle Region) (ABIN2789518)

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reaktivität: Human, Kaninchen, Schwein, Pferd, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MCAM Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: MCAM Antibody - middle region

Sequenz: PSTREAEEET TNDNGVLVLE PARKEHSGRY ECQGLDLDTM ISLLSEPQEL

Homologie: Cow: 86%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against MCAM. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63483-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Andere Bezeichnung: MCAM

Hintergrund:

Background Information: MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Gene Name: Melanoma cell adhesion molecule

Alternative Symbols: CD146, MUC18, HEMCAM, METCAM, MelCAM

Protein Name: Cell surface glycoprotein MUC18

Molekulargewicht: 71kDa

Gen-ID: 4162

NCBI Accession: NP_006491

UniProt: P43121