PRNP Antikörper (Middle Region)

Produktnummer ABIN2789398

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PRNP in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Rind (Kuh), Schaf, Hund und Ziege.

Kurzübersicht für PRNP Antikörper (Middle Region) (ABIN2789398)

Target: PRNP (Prion Protein (PRNP))

Reaktivität: Human, Ratte, Rind (Kuh), Schaf, Hund, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PRNP Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Prnp Antibody - middle region

Sequenz: GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Human: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Prnp. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Prnp

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63174-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PRNP

Target: PRNP (Prion Protein (PRNP))

Andere Bezeichnung: Prnp

Hintergrund:

Background Information: Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.

Gene Name: prion protein

Alternative Symbols: P, S, PrP, PrPC, Sinc, CD230, PrPSc, Prn-i, Prn-p, PrP, AA960666, AI325101, prP27-30, prP33-35C

Protein Name: Major prion protein

Molekulargewicht: 28kDa

Gen-ID: 19122

NCBI Accession: NP_035300

UniProt: P04925

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation