HLA-E Antikörper (C-Term)

Produktnummer ABIN2789266

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HLA-E in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Schwein.

Kurzübersicht für HLA-E Antikörper (C-Term) (ABIN2789266)

Target: HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))

Reaktivität: Human, Maus, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HLA-E Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: HLA-E Antibody - C-terminal region

Sequenz: IPIVGIIAGL VLLGSVVSGA VVAAVIWRKK SSGGKGGSYS KAEWSDSAQG

Homologie: Human: 100%, Mouse: 100%, Pig: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-E. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62847-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-E

Target: HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))

Andere Bezeichnung: HLA-E

Hintergrund:

Background Information: HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Gene Name: Major histocompatibility complex, class I, E

Alternative Symbols: QA1, HLA-6.2

Protein Name: HLA class I histocompatibility antigen, alpha chain E

Molekulargewicht: 38kDa

Gen-ID: 3133

NCBI Accession: NP_005507

UniProt: P13747

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response