RASGRP4 Antikörper (N-Term)

Produktnummer ABIN2789029

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RASGRP4 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Schwein.

Kurzübersicht für RASGRP4 Antikörper (N-Term) (ABIN2789029)

Target: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASGRP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RASGRP4 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: RASGRP4 Antibody - N-terminal region

Sequenz: FWATVAREGN SAQRRLGDSS DLLSPGGPGP PLPMSSPGLG KKRKVSLLFD

Homologie: Human: 100%, Pig: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against RASGRP4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62124-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu RASGRP4

Target: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Andere Bezeichnung: RASGRP4

Hintergrund:

Background Information: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: RAS guanyl releasing protein 4

Alternative Symbols: -

Protein Name: RAS guanyl-releasing protein 4

Molekulargewicht: 63kDa

Gen-ID: 115727

NCBI Accession: NP_001139679

UniProt: C0LTP7

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling