BRCC3 Antikörper (C-Term)

Produktnummer ABIN2788976

Produktdetails anti-BRCC3 Antikörper

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: HNGSVFTKNL CSQMSAVSGP LLQWLEDRLE QNQQHLQELQ QEKEELMQEL

Homologie: Cow: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against BRCC3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 316 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BRCC3

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Andere Bezeichnung: BRCC3 (BRCC3 Produkte)

Synonyme: CXorf53 antikoerper, BRCC3 antikoerper, xtp1 antikoerper, brcc3 antikoerper, BRCC36 antikoerper, brcc36 antikoerper, C6.1A antikoerper, BRCA1/BRCA2-containing complex subunit 3 antikoerper, DEP domain containing 1B antikoerper, BRCA1/BRCA2-containing complex, subunit 3 antikoerper, BRCA1/BRCA2-containing complex subunit 3 L homeolog antikoerper, BRCC3 antikoerper, depdc1b antikoerper, brcc3 antikoerper, Brcc3 antikoerper, brcc3.L antikoerper

Hintergrund: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
Alias Symbols: BRCC36, C6.1A, CXorf53, RP11-143H17.2
Protein Interaction Partner: FAM175B, UBC, FANCG, UIMC1, SUMO1, RABEP2, SMEK1, LARP7, CD2AP, WDHD1, SF3A1, GPHN, HNRNPR, TRIM28, HUWE1, MTA2, SPAG9, CCDC6, HDAC1, NR3C1, FAM175A, SUMO2, PAXIP1, MDC1, BRCA1, GRB2, BABAM1, BRE, BRCC3, COPS5, BACH1, BRCA2, BARD1, USP7, SHMT2, NDUFA10, M
Protein Size: 316

Molekulargewicht: 35 kDa

Gen-ID: 79184

NCBI Accession: NM_024332, NP_077308

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus