BAG4 Antikörper (C-Term)

Produktnummer ABIN2788954

Produktdetails anti-BAG4 Antikörper

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EVEEFVGKKT DKAYWLLEEM LTKELLELDS VETGGQDSVR QARKEAVCKI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against BAG4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 457 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Andere Bezeichnung: BAG4 (BAG4 Produkte)

Hintergrund: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alias Symbols: BAG-4, SODD
Protein Interaction Partner: EDC3, DCP1A, DNAJB12, DNAJC9, CD93, STUB1, DNAJB6, MLF2, DNAJC7, DNAJB1, HSPA8, HSPA2, HSPA1L, HSPA1B, DDX6, DCP1B, MCL1, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL5, NEDD8, ELAVL1, UBC, TNFRSF25, APOBEC1, TNFRSF1A, BCL2, HSPA1A, HSP90AA1, HSPA4,
Protein Size: 457

Molekulargewicht: 50 kDa

Gen-ID: 9530

NCBI Accession: NM_004874, NP_004865

UniProt: O95429

Pathways: Regulation of Actin Filament Polymerization