PKN2 Antikörper (C-Term)

Produktnummer ABIN2788942

Produktdetails anti-PKN2 Antikörper

Target: PKN2 (Protein Kinase N2 (PKN2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 77%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against Pkn2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Pkn2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PKN2

Target: PKN2 (Protein Kinase N2 (PKN2))

Andere Bezeichnung: Pkn2 (PKN2 Produkte)

Synonyme: PAK2 antikoerper, PRK2 antikoerper, PRKCL2 antikoerper, PRO2042 antikoerper, Pak-2 antikoerper, 6030436C20Rik antikoerper, AI507382 antikoerper, Prkcl2 antikoerper, Stk7 antikoerper, pak2 antikoerper, prk2 antikoerper, pak-2 antikoerper, pro2042 antikoerper, PKN2 antikoerper, si:ch211-83f14.1 antikoerper, wu:fa97c07 antikoerper, protein kinase N2 antikoerper, protein kinase N2 L homeolog antikoerper, PKN2 antikoerper, Pkn2 antikoerper, pkn2.L antikoerper, pkn2 antikoerper

Hintergrund: Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983

Molekulargewicht: 111 kDa

Gen-ID: 109333

NCBI Accession: NM_178654, NP_848769

UniProt: Q8BWW9

Pathways: Cell-Cell Junction Organization