Shugoshin Antikörper (C-Term)

Produktnummer ABIN2788840

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Shugoshin in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Pferd.

Kurzübersicht für Shugoshin Antikörper (C-Term) (ABIN2788840)

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Reaktivität: Human, Ratte, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Shugoshin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Shugoshin Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SGO1 Antibody - C-terminal region

Sequenz: NSDRPVTRPL AKRALKYTDE KETEGSKPTK TPTTTPPETQ QSPHLSLKDI

Homologie: Horse: 91%, Human: 100%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against SGOL1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SGOL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61569-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Shugoshin

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Andere Bezeichnung: SGO1

Hintergrund:

Background Information: The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.

Gene Name: shugoshin 1

Alternative Symbols: SGO, CAID, SGOL1, NY-BR-85

Protein Name: shugoshin 1

Molekulargewicht: 60kDa

Gen-ID: 151648

NCBI Accession: NP_001012409

UniProt: B5BUA4

Pathways: Maintenance of Protein Location