GALR2 Antikörper (C-Term)

Produktnummer ABIN786413

Der Kaninchen Polyklonal Anti-GALR2-Antikörper wurde für WB validiert. Er ist geeignet, GALR2 in Proben von Human und Pferd zu detektieren.

Kurzübersicht für GALR2 Antikörper (C-Term) (ABIN786413)

Target: GALR2 (Galanin Receptor 2 (GALR2))

Reaktivität: Human, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GALR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GALR2 Antikörper

Bindungsspezifität: C-Term

Sequenz: RGTHSGSVLE RESSDLLHMS EAAGALRPCP GASQPCILEP CPGPSWQGPK

Homologie: Horse: 93%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GALR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 387 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GALR2

Target: GALR2 (Galanin Receptor 2 (GALR2))

Andere Bezeichnung: GALR2

Hintergrund: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Alias Symbols: GALNR2, MGC125983, MGC125984
Protein Interaction Partner: GNAQ, GAL,
Protein Size: 387

Molekulargewicht: 43 kDa

Gen-ID: 8811

NCBI Accession: NM_003857, NP_003848

UniProt: O43603

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour