Hexosaminidase A Antikörper (C-Term)

Produktnummer ABIN2788673

Der Kaninchen Polyklonal anti-Hexosaminidase A Antikörper (ABIN2788673) detektiert spezifisch Hexosaminidase A in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Meerschweinchen, Schwein, Rind (Kuh), Pferd, Kaninchen und Schaf.

Kurzübersicht für Hexosaminidase A Antikörper (C-Term) (ABIN2788673)

Target: Hexosaminidase A (HEXA)

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Schwein, Rind (Kuh), Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hexosaminidase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Hexosaminidase A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: HEXA Antibody - C-terminal region

Sequenz: WKDFYIVEPL AFEGTPEQKA LVIGGEACMW GEYVDNTNLV PRLWPRAGAV

Homologie: Cow: 93%, Dog: 85%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HEXA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HEXA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61100-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Hexosaminidase A

Target: Hexosaminidase A (HEXA)

Andere Bezeichnung: HEXA

Hintergrund:

Targeted Subunit: alpha

Background Information: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Gene Name: Hexosaminidase A (alpha polypeptide)

Alternative Symbols: TSD

Protein Name: Beta-hexosaminidase subunit alpha

Molekulargewicht: 61 kDa

Gen-ID: 3073

NCBI Accession: NP_000511

UniProt: P06865

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process