Hexosaminidase A Antikörper (C-Term)

Produktnummer ABIN2788673

Produktdetails anti-Hexosaminidase A Antikörper

Target: Hexosaminidase A (HEXA)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Schwein, Rind (Kuh), Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hexosaminidase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: WKDFYIVEPL AFEGTPEQKA LVIGGEACMW GEYVDNTNLV PRLWPRAGAV

Homologie: Cow: 93%, Dog: 85%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against HEXA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HEXA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 529 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Hexosaminidase A

Target: Hexosaminidase A (HEXA)

Andere Bezeichnung: HEXA (HEXA Produkte)

Synonyme: TSD antikoerper, fc04h11 antikoerper, wu:fc04h11 antikoerper, wu:fv09f06 antikoerper, si:dkey-35i22.2 antikoerper, HEXA antikoerper, Hex-1 antikoerper, zgc:112084 antikoerper, hexosaminidase subunit alpha antikoerper, hexosaminidase B (beta polypeptide) antikoerper, CUGBP Elav-like family member 6 antikoerper, hexosaminidase A antikoerper, hexosaminidase A (alpha polypeptide) antikoerper, beta-hexosaminidase subunit alpha-like antikoerper, HEXA antikoerper, hexb antikoerper, CELF6 antikoerper, Hexa antikoerper, hexa antikoerper, LOC100228061 antikoerper

Hintergrund: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
Alias Symbols: MGC99608, TSD
Protein Interaction Partner: H2AFV, WDR61, UBA6, UBR7, C9orf78, HERC4, FKBP9, PDCD10, NUBP2, GTF3C4, HIST1H2BO, XPNPEP1, EZR, RAD23A, PCNA, KTN1, HK1, GDI1, CAPZB, AHCY, ACAT2, FBXO6, H2AFX, GM2A, USP22,
Protein Size: 529

Molekulargewicht: 48 kDa

Gen-ID: 3073

NCBI Accession: NM_000520, NP_000511

UniProt: P06865

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process