Topoisomerase I Antikörper (N-Term)

Produktnummer ABIN2788658

Dieses Anti-Topoisomerase I-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Topoisomerase I in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen und Hund.

Kurzübersicht für Topoisomerase I Antikörper (N-Term) (ABIN2788658)

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Topoisomerase I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Topoisomerase I Antikörper

Bindungsspezifität: N-Term

Sequenz: SNSEHKDSEK KHKEKEKTKH KDGSSEKHKD KHKDRDKEKR KEEKVRASGD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TOP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 765 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Topoisomerase I

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Andere Bezeichnung: TOP1

Hintergrund: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Alias Symbols: TOPI
Protein Interaction Partner: SUMO2, SUMO3, MDM2, UBC, SUMO1, ERG, RNF2, EED, SHFM1, CDK14, TARDBP, CDK2, HDAC9, EIF2AK2, PARP1, WHSC1, VCAM1, ITGA4, IL7R, VCP, PA2G4, NKX3-1, ESR1, RBM39, APP, UTP20, NCSTN, SUPT16H, RBM14, SF3B6, SRSF11, TPR, SNRPD1, S100A9, RPS14, HNRNPM, IK, HNRNPC
Protein Size: 765

Molekulargewicht: 91 kDa

Gen-ID: 7150

NCBI Accession: NM_003286, NP_003277

UniProt: P11387

Pathways: Caspase Kaskade in der Apoptose, Stem Cell Maintenance