Factor VIII Antikörper (C-Term)

Produktnummer ABIN2788318

Der Kaninchen Polyklonal anti-Factor VIII Antikörper wird verwendet zum Nachweis von Factor VIII in Proben von Human, Hund, Rind (Kuh), Kaninchen, Schaf und Pferd. Er wurde validiert für WB.

Kurzübersicht für Factor VIII Antikörper (C-Term) (ABIN2788318)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human, Hund, Rind (Kuh), Kaninchen, Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Factor VIII Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Factor VIII Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: F8 Antibody - C-terminal region

Sequenz: IMVTFRNQAS RPYSFYSSLI SYEEDQRQGA EPRKNFVKPN ETKTYFWKVQ

Homologie: Cow: 86%, Dog: 77%, Horse: 93%, Human: 100%, Rabbit: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against F8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human F8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60040-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Andere Bezeichnung: F8

Hintergrund:

Background Information: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene Name: Coagulation factor VIII, procoagulant component

Alternative Symbols: AHF, F8B, F8C, HEMA, FVIII, DXS1253E

Protein Name: Coagulation factor VIII

Molekulargewicht: 79kDa

Gen-ID: 2157

NCBI Accession: NP_000123

UniProt: P00451