Factor VIII Antikörper (C-Term)

Produktnummer ABIN2788318

Der Kaninchen Polyklonal Anti-Factor VIII-Antikörper wurde für WB validiert. Er ist geeignet, Factor VIII in Proben von Human, Hund, Kaninchen, Rind (Kuh), Schaf und Pferd zu detektieren.

Kurzübersicht für Factor VIII Antikörper (C-Term) (ABIN2788318)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human, Hund, Kaninchen, Rind (Kuh), Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Factor VIII Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Factor VIII Antikörper

Bindungsspezifität: C-Term

Sequenz: IMVTFRNQAS RPYSFYSSLI SYEEDQRQGA EPRKNFVKPN ETKTYFWKVQ

Homologie: Cow: 86%, Dog: 77%, Horse: 93%, Human: 100%, Rabbit: 86%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against F8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human F8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2351 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Andere Bezeichnung: F8

Hintergrund: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Alias Symbols: AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Protein Interaction Partner: UBQLN1, GGA1, MCFD2, PHYH, LMAN1, F9, F10, VWF, F2, PROS1, PROC, HSPA5, CANX, CALR, ASGR2, LRP1,
Protein Size: 2351

Molekulargewicht: 79 kDa

Gen-ID: 2157

NCBI Accession: NM_000132, NP_000123

UniProt: P00451