ADRA2A Antikörper (C-Term)

Produktnummer ABIN2788284

Der Kaninchen Polyklonal Anti-ADRA2A Antikörper wurde für WB validiert. Er ist geeignet, ADRA2A in Proben von Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen und Schwein zu detektieren.

Kurzübersicht für ADRA2A Antikörper (C-Term) (ABIN2788284)

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ADRA2A Antikörper

Bindungsspezifität: C-Term

Sequenz: RRPERGPRGK GKARASQVKP GDSLPRRGPG ATGIGTPAAG PGEERVGAAK

Homologie: Cow: 92%, Dog: 85%, Guinea Pig: 79%, Human: 100%, Mouse: 79%, Pig: 85%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ADRA2A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ADRA2A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 450 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ADRA2A

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Andere Bezeichnung: ADRA2A

Hintergrund: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons, the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
Alias Symbols: ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Protein Interaction Partner: GNAO1, ADRA2A, SNTA1, GNG2, GNB1, GNAI2, UCHL1, EIF2B1, YWHAZ, PRKCD, GNAI1, ADRBK1, ADRB1, PPP1R9B,
Protein Size: 450

Molekulargewicht: 49 kDa

Gen-ID: 150

NCBI Accession: NM_000681, NP_000672

UniProt: P08913

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity