HNMT Antikörper (N-Term)

Produktnummer ABIN2788140

Produktdetails anti-HNMT Antikörper

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PGIIGRIGDT KSEIKILSIG GGAGEIDLQI LSKVQAQYPG VCINNEVVEP

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 77%, Horse: 92%, Human: 100%, Mouse: 77%, Pig: 92%, Rabbit: 92%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HNMT. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNMT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 292 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HNMT

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Andere Bezeichnung: HNMT (HNMT Produkte)

Hintergrund: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Alias Symbols: HMT, HNMT-S1, HNMT-S2
Protein Interaction Partner: CAMK2D, DSP, TINF2, POT1, TERF1,
Protein Size: 292

Molekulargewicht: 33 kDa

Gen-ID: 3176

NCBI Accession: NM_006895, NP_008826

UniProt: P50135