GCH1 Antikörper (N-Term)

Produktnummer ABIN2788139

Der Kaninchen Polyklonal anti-GCH1 Antikörper wird verwendet zum Nachweis von GCH1 in Proben von Human, Ratte, Rind (Kuh), Hund und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für GCH1 Antikörper (N-Term) (ABIN2788139)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GCH1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GCH1 Antibody - N-terminal region

Sequenz: PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Rabbit: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GCH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59619-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Andere Bezeichnung: GCH1

Hintergrund:

Background Information: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.

Gene Name: GTP cyclohydrolase 1

Alternative Symbols: GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1

Protein Name: GTP cyclohydrolase 1

Molekulargewicht: 27kDa

Gen-ID: 2643

UniProt: P30793