GCH1 Antikörper (N-Term)

Produktnummer ABIN2788139

Der Kaninchen Polyklonal anti-GCH1 Antikörper wird verwendet zum Nachweis von GCH1 in Proben von Human, Ratte, Rind (Kuh), Hund und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für GCH1 Antikörper (N-Term) (ABIN2788139)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GCH1 Antikörper

Bindungsspezifität: N-Term

Sequenz: PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Rabbit: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GCH1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Andere Bezeichnung: GCH1

Hintergrund: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Protein Interaction Partner: GCH1, CALML6, CAMKK1, CSNK1G1, CALML5, PACSIN3, RGS19, MAP2K4, MAPK12, MAP2K5, MAPK10, PRKAR2B, PRKAR2A, PPM1B, CSNK2B, CSNK2A1, GIT2, YWHAZ, CNRIP1, RAB26, AHSA1, SP3, RLF, HSPA8, GCHFR, ATP1B1, CDC37, SH3GL2, OSBPL9, RPH3A,
Protein Size: 250

Molekulargewicht: 27 kDa

Gen-ID: 2643

UniProt: P30793