GCH1 Antikörper (C-Term)

Produktnummer ABIN2788138

Der Kaninchen Polyklonal Anti-GCH1-Antikörper wurde für WB validiert. Er ist geeignet, GCH1 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Saccharomyces cerevisiae und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für GCH1 Antikörper (C-Term) (ABIN2788138)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GCH1 Antikörper

Bindungsspezifität: C-Term

Sequenz: LRPAGVGVVV EATHMCMVMR GVQKMNSKTV TSTMLGVFRE DPKTREEFLT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GCH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 250 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Andere Bezeichnung: GCH1

Hintergrund: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Alias Symbols: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Protein Interaction Partner: GCH1, CALML6, CAMKK1, CSNK1G1, CALML5, PACSIN3, RGS19, MAP2K4, MAPK12, MAP2K5, MAPK10, PRKAR2B, PRKAR2A, PPM1B, CSNK2B, CSNK2A1, GIT2, YWHAZ, CNRIP1, RAB26, AHSA1, SP3, RLF, HSPA8, GCHFR, ATP1B1, CDC37, SH3GL2, OSBPL9, RPH3A,
Protein Size: 250

Molekulargewicht: 28 kDa

Gen-ID: 2643

NCBI Accession: NM_000161, NP_000152

UniProt: P30793