MANF Antikörper (C-Term)

Produktnummer ABIN2788136

Produktdetails anti-MANF Antikörper

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Pferd, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MANF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MANF. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MANF

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 185 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MANF

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Andere Bezeichnung: MANF (MANF Produkte)

Synonyme: ARMET antikoerper, ARP antikoerper, 3230402M22Rik antikoerper, AA407711 antikoerper, AA408789 antikoerper, AA673178 antikoerper, Armet antikoerper, D17914 antikoerper, D18Mgi17 antikoerper, MANF antikoerper, RBM15B antikoerper, ARP-like antikoerper, CG7013 antikoerper, DmMANF antikoerper, Dmel\\CG7013 antikoerper, anon-EST:ParkEST188 antikoerper, arp antikoerper, armet antikoerper, im:6909481 antikoerper, zgc:153327 antikoerper, manf antikoerper, mesencephalic astrocyte derived neurotrophic factor antikoerper, mesencephalic astrocyte-derived neurotrophic factor antikoerper, RNA binding motif protein 15B antikoerper, Mesencephalic astrocyte-derived neurotrophic factor antikoerper, mesencephalic astrocyte-derived neurotrophic factor S homeolog antikoerper, MANF antikoerper, Manf antikoerper, RBM15B antikoerper, manf antikoerper, manf.S antikoerper

Hintergrund: MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Alias Symbols: ARMET, ARP, MGC142148, MGC142150
Protein Interaction Partner: UBC, MDM2,
Protein Size: 185

Molekulargewicht: 21 kDa

Gen-ID: 7873

NCBI Accession: NM_006010, NP_006001

UniProt: A8K878