AVPR2 Antikörper (C-Term)

Produktnummer ABIN2788110

Der Kaninchen Polyklonal anti-AVPR2 Antikörper wird verwendet zum Nachweis von AVPR2 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf und Pferd. Er wurde validiert für WB.

Kurzübersicht für AVPR2 Antikörper (C-Term) (ABIN2788110)

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-AVPR2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: AVPR2 Antibody - C-terminal region

Sequenz: NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS

Homologie: Cow: 79%, Dog: 79%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against AVPR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AVPR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59538-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu AVPR2

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Andere Bezeichnung: AVPR2

Hintergrund:

Background Information: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.

Gene Name: Arginine vasopressin receptor 2

Alternative Symbols: DI1, DIR, NDI, V2R, ADHR, DIR3

Protein Name: Vasopressin V2 receptor

Molekulargewicht: 40 kDa

Gen-ID: 554

NCBI Accession: NP_000045

UniProt: P30518

Pathways: cAMP Metabolic Process