AVPR2 Antikörper (C-Term)

Produktnummer ABIN2788110

Produktdetails anti-AVPR2 Antikörper

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AVPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS

Homologie: Cow: 79%, Dog: 79%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against AVPR2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AVPR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 371 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu AVPR2

Target: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Andere Bezeichnung: AVPR2 (AVPR2 Produkte)

Synonyme: AVPR2 antikoerper, ADHR antikoerper, DI1 antikoerper, DIR antikoerper, DIR3 antikoerper, NDI antikoerper, V2R antikoerper, ND1 antikoerper, VPV2R antikoerper, arginine vasopressin receptor 2 antikoerper, AVPR2 antikoerper, Avpr2 antikoerper

Hintergrund: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
Alias Symbols: ADHR, DI1, DIR, DIR3, MGC126533, MGC138386, NDI, V2R
Protein Interaction Partner: ARRDC4, ARRDC3, GNG2, GNB1, GNAS, STUB1, UBC, DERL1, VCP, C1QTNF1, GRK5, AVP, ARRB2, MAPK3, PRKCA,
Protein Size: 371

Molekulargewicht: 40 kDa

Gen-ID: 554

NCBI Accession: NM_000054, NP_000045

UniProt: P30518

Pathways: cAMP Metabolic Process