PEN2 Antikörper (C-Term)

Produktnummer ABIN2788066

Dieser Anti-PEN2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von PEN2 in WB. Geeignet für Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen und Zebrafisch (Danio rerio).

Kurzübersicht für PEN2 Antikörper (C-Term) (ABIN2788066)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PEN2 Antikörper

Bindungsspezifität: C-Term

Sequenz: SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PSENEN. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 101 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: PSENEN

Hintergrund: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A, ERLIN2, THBD, APH1B, PSEN2, PSEN1, TMED10, NCSTN,
Protein Size: 101

Molekulargewicht: 12 kDa

Gen-ID: 55851

NCBI Accession: NM_172341, NP_758844

UniProt: Q9NZ42

Pathways: Notch Signalweg, Neurotrophin Signalübertragung