NAE1 Antikörper (C-Term)
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- Target Alle NAE1 Antikörper anzeigen
- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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Bindungsspezifität
- C-Term
- Reaktivität
- Human, Maus, Ratte, Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NAE1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- ARALKEFVAK EGQGNLPVRG TIPDMIADSN KYIKLQNVYR EKAKKDAAAV
- Homologie
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Nae1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nae1
- Top Product
- Discover our top product NAE1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 534 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
- Andere Bezeichnung
- Nae1 (NAE1 Produkte)
- Synonyme
- APPBP1 antikoerper, CG7828 antikoerper, Dmel\\CG7828 antikoerper, anon-WO0140519.225 antikoerper, dAPP-BP1 antikoerper, dAPPBP1 antikoerper, A-116A10.1 antikoerper, ula-1 antikoerper, Appbp1 antikoerper, 59kDa antikoerper, appbp1 antikoerper, zgc:66148 antikoerper, beta-Amyloid precursor protein binding protein 1 antikoerper, NEDD8 activating enzyme E1 subunit 1 antikoerper, NEDD8 activating enzyme E1 subunit 1 S homeolog antikoerper, nedd8 activating enzyme E1 subunit 1 antikoerper, NEDD8-activating enzyme E1 regulatory subunit antikoerper, APP-BP1 antikoerper, NAE1 antikoerper, Nae1 antikoerper, nae1.S antikoerper, nae1 antikoerper, ula-1 antikoerper
- Hintergrund
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Nae1 is a regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Alias Symbols: 59 kDa, Appbp1
Protein Size: 534 - Molekulargewicht
- 60 kDa
- Gen-ID
- 234664
- NCBI Accession
- NM_144931, NP_659180
- UniProt
- Q8VBW6
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