USP20 Antikörper (Middle Region)

Produktnummer ABIN2788022

Der Kaninchen Polyklonal Anti-USP20-Antikörper wurde für WB validiert. Er ist geeignet, USP20 in Proben von Human, Maus, Ratte, Hund, Kaninchen, Pferd, Rind (Kuh) und Meerschweinchen zu detektieren.

Kurzübersicht für USP20 Antikörper (Middle Region) (ABIN2788022)

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Pferd, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-USP20 Antikörper

Bindungsspezifität: Middle Region

Sequenz: PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against USP20. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human USP20

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 913 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu USP20

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Andere Bezeichnung: USP20

Hintergrund: USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Alias Symbols: KIAA1003, LSFR3A, VDU2
Protein Interaction Partner: MDFI, MAGEA11, TRIM23, ALAS1, FATE1, BEND5, SPRY2, VAPB, CCDC36, BEND7, RAD17, NEURL4, USP33, USP20, CCP110, ADRB2, PJA1, USP28, USP21, USP15, PLA2G2A, UBC, VHL, HIF1A, VAPA, HERC2P2, PLEKHA7, SYTL4, GPT2, POLDIP3, RGPD5, ATAD3B, MAP7D1, LRRC59, ZNF770, S
Protein Size: 913

Molekulargewicht: 102 kDa

Gen-ID: 10868

NCBI Accession: NM_006676, NP_006667

UniProt: Q9Y2K6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling